Novokines

De novo designed cytokines

Expòsit M*, Abedi M.H.*, et al. “Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling.” bioRxiv

2025

Abedi M.H.*, Expòsit M*, et al. “High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists.” bioRxiv

2025

Broerman, Adam J, … , Abedi, M. H., …, et al. “Design of facilitated dissociation enables timing of cytokine signalling.” Nature

Broerman, Adam J, … , Abedi, M. H., …, et al. “Design of facilitated dissociation enables timing of cytokine signalling.” Nature

2025

Keshri R, Exposit M, Abedi M.H.,et al. “Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity.” bioRxiv

2025

Huang, Buwei, …, Abedi, M. H., …, et al. “De novo design of miniprotein antagonists of cytokine storm inducers.” Nature comm.

Huang, Buwei, …, Abedi, M. H., …, et al. “De novo design of miniprotein antagonists of cytokine storm inducers.” Nature comm.

2024

Synthetic Signaling

De novo design of orthogonal signaling networks and modulators

Piraner, Dan*, Abedi M.H.*, et al. “Engineered receptors for soluble cellular communication and disease sensing.” Nature

Piraner, Dan*, Abedi M.H.*, et al. “Engineered receptors for soluble cellular communication and disease sensing.” Nature

2025

Huang, Buwei*, Abedi M. H.*, et al. “Designed endocytosis-inducing proteins degrade targets and amplify signals.” Nature

Huang, Buwei*, Abedi M. H.*, et al. “Designed endocytosis-inducing proteins degrade targets and amplify signals.” Nature

2025

Vázquez Torres, Susana, … , Abedi, M. H., … , et al. “De novo designed proteins neutralize lethal snake venom toxins.” Nature

Vázquez Torres, Susana, … , Abedi, M. H., … , et al. “De novo designed proteins neutralize lethal snake venom toxins.” Nature

2025

Yang, E.C., … , Abedi, M. H., … , et al. Computational design of non-porous pH-responsive antibody nanoparticles. Nat Struct Mol Biol

Yang, E.C., … , Abedi, M. H., … , et al. Computational design of non-porous pH-responsive antibody nanoparticles. Nat Struct Mol Biol

2024

Motmaen, Amir, … , Abedi, M. H., … , et al. “Peptide-binding specificity prediction ...” PNAS

Motmaen, Amir, … , Abedi, M. H., … , et al. “Peptide-binding specificity prediction ...” PNAS

2023

Ultrasound

Ultrasound imaging and control of cells

Liu, Ann, …, Abedi, M. H., …, et al. “Thermally Controlled State Switches for Engineered Macrophages.” ACS synthetic biology

Liu, Ann, …, Abedi, M. H., …, et al. “Thermally Controlled State Switches for Engineered Macrophages.” ACS synthetic biology

2025

Shivaei S, Liu A, Abedi M, et al. “Non-invasive imaging of cell-based therapies using acoustic reporter genes.” bioRxiv

Shivaei S, Liu A, Abedi M, et al. “Non-invasive imaging of cell-based therapies using acoustic reporter genes.” bioRxiv

2024

Hurt, Robert C, …, Abedi, M. H., …, et al. “Genomically mined acoustic reporter genes for real-time in vivo monitoring ...” Nature biotech

Hurt, Robert C, …, Abedi, M. H., …, et al. “Genomically mined acoustic reporter genes for real-time in vivo monitoring ...” Nature biotech

2023

Abedi, M. H.* Yao, M.* et al. “Ultrasound-controllable engineered bacteria for cancer immunotherapy.” Nature communications

Abedi, M. H.* Yao, M.* et al. “Ultrasound-controllable engineered bacteria for cancer immunotherapy.” Nature communications

2022

Bar-Zion, A. …, Abedi, M. H., …, et al. “Acoustically triggered mechanotherapy using genetically encoded gas vesicles” Nature nanotech

Bar-Zion, A. …, Abedi, M. H., …, et al. “Acoustically triggered mechanotherapy using genetically encoded gas vesicles” Nature nanotech

2021

Abedi, M. H. et al. “Thermal Control of Engineered T-cells.” ACS synthetic biology

Abedi, M. H. et al. “Thermal Control of Engineered T-cells.” ACS synthetic biology

2020

Piraner, Dan I*, Abedi, M. H.* et al. “Tunable thermal bioswitches for in vivo control of microbial therapeutics.” Nature chemical biology

Piraner, Dan I*, Abedi, M. H.* et al. “Tunable thermal bioswitches for in vivo control of microbial therapeutics.” Nature chemical biology

2017

© 2026 Abedi Lab - our lab exists on lands originally and still cared for by the Tongva, Tataviam, Serrano, Kizh, and Chumash peoples, and we honor their elders and descendants.
© 2026 Abedi Lab - our lab exists on lands originally and still cared for by the Tongva, Tataviam, Serrano, Kizh, and Chumash peoples, and we honor their elders and descendants.
© 2026 Abedi Lab - our lab exists on lands originally and still cared for by the Tongva, Tataviam, Serrano, Kizh, and Chumash peoples, and we honor their elders and descendants.