Novokines
De novo designed cytokines
Expòsit M*, Abedi M.H.*, et al. “Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling.” bioRxiv
2025
Abedi M.H.*, Expòsit M*, et al. “High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists.” bioRxiv
2025
Broerman, Adam J, … , Abedi, M. H., …, et al. “Design of facilitated dissociation enables timing of cytokine signalling.” Nature
2025
Keshri R, Exposit M, Abedi M.H.,et al. “Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity.” bioRxiv
2025
Huang, Buwei, …, Abedi, M. H., …, et al. “De novo design of miniprotein antagonists of cytokine storm inducers.” Nature comm.
2024
Synthetic Signaling
De novo design of orthogonal signaling networks and modulators
Piraner, Dan*, Abedi M.H.*, et al. “Engineered receptors for soluble cellular communication and disease sensing.” Nature
2025
Huang, Buwei*, Abedi M. H.*, et al. “Designed endocytosis-inducing proteins degrade targets and amplify signals.” Nature
2025
Vázquez Torres, Susana, … , Abedi, M. H., … , et al. “De novo designed proteins neutralize lethal snake venom toxins.” Nature
2025
Yang, E.C., … , Abedi, M. H., … , et al. Computational design of non-porous pH-responsive antibody nanoparticles. Nat Struct Mol Biol
2024
Motmaen, Amir, … , Abedi, M. H., … , et al. “Peptide-binding specificity prediction ...” PNAS
2023
Ultrasound
Ultrasound imaging and control of cells
Liu, Ann, …, Abedi, M. H., …, et al. “Thermally Controlled State Switches for Engineered Macrophages.” ACS synthetic biology
2025
Vázquez Torres, Susana, …, Abedi, M. H., …, et al. “De novo designed proteins neutralize lethal snake venom toxins.” Nature
2025
Shivaei S, Liu A, Abedi M, et al. “Non-invasive imaging of cell-based therapies using acoustic reporter genes.” bioRxiv
2024
Hurt, Robert C, …, Abedi, M. H., …, et al. “Genomically mined acoustic reporter genes for real-time in vivo monitoring ...” Nature biotech
2023
Abedi, M. H.* Yao, M.* et al. “Ultrasound-controllable engineered bacteria for cancer immunotherapy.” Nature communications
2022
Bar-Zion, A. …, Abedi, M. H., …, et al. “Acoustically triggered mechanotherapy using genetically encoded gas vesicles” Nature nanotech
2021
Abedi, M. H. et al. “Thermal Control of Engineered T-cells.” ACS synthetic biology
2020
Piraner, Dan I*, Abedi, M. H.* et al. “Tunable thermal bioswitches for in vivo control of microbial therapeutics.” Nature chemical biology
2017
Project F
2025